Overview

  • Product name

    Artesunate, artemisinin derivative
  • Description

    Semi-synthetic artemisinin derivative
  • Biological description

    Semi-synthetic artemisinin (Asc-1308) derivative. Induces apoptosis of vascular endothelial cells. Shows antiangiogenenic and antiparasitaemic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    88495-63-0
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    384.42
  • Molecular formula

    C19H28O8
  • PubChem identifier

    65664
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C
  • Source

    Artemisia annua

  • Research areas

References

This product has been referenced in:

  • Lombard MC  et al. Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids. Malar J 12:71 (2013). Read more (PubMed: 23433124) »
  • Cheng R  et al. The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells. Invest Ophthalmol Vis Sci 54:3400-9 (2013). Read more (PubMed: 23611999) »
  • Rutteman GR  et al. Safety and efficacy field study of artesunate for dogs with non-resectable tumours. Anticancer Res 33:1819-27 (2013). Read more (PubMed: 23645726) »

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