Key features and details
- Potent, selective, ATP competitive JNK inhibitor. Cell-permeable.
- CAS Number: 345987-15-7
- Purity: > 95%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameAS601245, JNK inhibitor
DescriptionPotent, selective, ATP competitive JNK inhibitor. Cell-permeable.
Biological descriptionPotent, selective, ATP competitive JNK inhibitor (IC50 values are 150, 220 and 70 nM for hJNK1,2 and 3 respectively). Reduces cell adhesion and migration in cancer cells. Shows neuroprotective, anti-ischemic effects in vivo. Blood-brain barrier and cell-permeable.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Integration of energy
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145194 has not yet been referenced specifically in any publications.