Overview

  • Product name

    Asaraldehyde (Asaronaldehyde), COX-2 inhibitor
  • Description

    Selective COX-2 inhibitor
  • Biological description

    Selective COX-2 inhibitor. Suppresses adipogenesis and promotes lipolysis. Inhibits antigen-induced β-hexosaminidase release (IC50 = 24 μM). Suppresses PPARγ1 and PPARγ2 expression. Shows antifungal effects in vivo.
  • Purity

    > 99%
  • CAS Number

    4460-86-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,4,5-trimethoxybenzaldehyde
  • Molecular weight

    196.20
  • Molecular formula

    C10H12O4
  • PubChem identifier

    20525
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC(=C(C=C1C=O)OC)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Rajput SB  et al. Anti-Candida properties of asaronaldehyde of Acorus gramineus rhizome and three structural isomers. Chin Med 8:18 (2013). Read more (PubMed: 24010893) »
  • Wu MR  et al. 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes. J Agric Food Chem 60:7262-9 (2012). Read more (PubMed: 22746947) »
  • Park CH  et al. Phenolic constituents of Acorus gramineus. Arch Pharm Res 34:1289-96 (2011). Read more (PubMed: 21910050) »

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