Overview

  • Product name

  • Description

    Rabbit polyclonal to ASC1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-272 of Human ASC1 (Q15650).

  • Positive control

    • A549 and HCT116 whole cell lysates; Human colon carcinoma tissue.
  • General notes

    Keep as concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab127537 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 66 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function.
  • Cellular localization

    Nucleus. Cytoplasm. Cytoplasmic under conditions of serum deprivation.
  • Information by UniProt
  • Database links

  • Alternative names

    • Activating signal cointegrator 1 antibody
    • ASC 1 antibody
    • ASC-1 antibody
    • HsT17391 antibody
    • Thyroid hormone receptor interactor 4 antibody
    • Thyroid receptor interacting protein 4 antibody
    • Thyroid receptor-interacting protein 4 antibody
    • TR-interacting protein 4 antibody
    • TRIP 4 antibody
    • TRIP-4 antibody
    • Trip4 antibody
    • TRIP4_HUMAN antibody
    • ZC2HC5 antibody
    • Zinc finger C2HC5 type antibody
    see all

Images

  • Anti-ASC1 antibody (ab127537) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size: 66 kDa



    7.5% SDS PAGE
  • ab127537, at 1/250, staining ASC1 in paraffin embedded Human colon carcinoma tissue by Immunohistochemistry.

References

This product has been referenced in:

  • Zhu J  et al. Protective effects of Erigeron breviscapus Hand.- Mazz. (EBHM) extract in retinal neurodegeneration models. Mol Vis 24:315-325 (2018). Read more (PubMed: 29769797) »
  • Qi Y  et al. Retinal ischemia/reperfusion injury is mediated by Toll-like receptor 4 activation of NLRP3 inflammasomes. Invest Ophthalmol Vis Sci 55:5466-75 (2014). Read more (PubMed: 25097240) »
See all 2 Publications for this product

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