Overview

  • Product name

    Ascomycin, Calcineurin/PP2B inhibitor
  • Description

    Calcineurin/PP2B inhibitor. Immunosuppressant and antifungal activity.
  • Alternative names

    • FK 520
  • Biological description

    Calcineurin/PP2B inhibitor (IC50 = 49 nM). Forms a FK-506 binding protein 12 (FKBP12) - Ascomycin -Calcineurin complex. Immunosuppressant and antifungal activity in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    104987-12-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Sierra-Paredes G & Sierra-Marcuño G Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants. CNS Neurosci Ther 14:36-46 (2008). Read more (PubMed: 18482098) »
  • Vázquez-López A  et al. Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus. Pharmacol Biochem Behav 84:511-6 (2006). Read more (PubMed: 16872668) »
  • Revill WP  et al. Genetically engineered analogs of ascomycin for nerve regeneration. J Pharmacol Exp Ther 302:1278-85 (2002). Read more (PubMed: 12183690) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141016.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up