Overview

  • Product name

  • Description

    Rabbit polyclonal to ASCT-1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human ASCT-1 (internal sequence) conjugated to keyhole limpet haemocyanin.
    Database link: NP_003029.2

  • Positive control

    • Human Colon and Brain (basal Ganglia) tissues.
  • General notes

    Previously labelled as SLC1A4.

Properties

Applications

Our Abpromise guarantee covers the use of ab118454 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 15 - 20 µg/ml.

Target

  • Function

    Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.
  • Tissue specificity

    Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined.
  • Involvement in disease

    Spastic tetraplegia, thin corpus callosum, and progressive microcephaly
  • Sequence similarities

    Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A4 subfamily.
  • Cellular localization

    Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links

  • Alternative names

    • Alanine/serine/cysteine/threonine transporter 1 antibody
    • ASCT-1 antibody
    • ASCT1 antibody
    • AW045657 antibody
    • Glutamate/neutral amino acid transporter antibody
    • Neutral amino acid transporter A antibody
    • OTTHUMP00000159933 antibody
    • OTTHUMP00000235138 antibody
    • SATT antibody
    • SATT_HUMAN antibody
    • SLC1A4 antibody
    • Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 antibody
    • Solute carrier family 1 member 4 antibody
    see all

Images

  • ab118454, at 20 µg/ml, staining ASCT-1 in Formalin-fixed, Paraffin-embedded Human Colon tissue by Immunohistochemistry.

  • ab118454, at 20 µg/ml, staining ASCT-1 in Formalin-fixed, Paraffin-embedded Human Brain (basal Ganglia) tissue by Immunohistochemistry.

References

This product has been referenced in:

  • Allen M  et al. Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy. Acta Neuropathol 136:709-727 (2018). Read more (PubMed: 30136084) »
See 1 Publication for this product

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