Overview

  • Product name

  • Description

    Rabbit polyclonal to ASCT-1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to Human ASCT-1 aa 478-531.
    Sequence:

    NQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELES KESV


    Database link: P43007

  • Positive control

    • Human oral mucosa tissue; A431 cells.
  • General notes

    Previously labelled as SLC1A4.

Properties

Applications

Our Abpromise guarantee covers the use of ab204348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100.

IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.
  • Tissue specificity

    Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined.
  • Involvement in disease

    Spastic tetraplegia, thin corpus callosum, and progressive microcephaly
  • Sequence similarities

    Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A4 subfamily.
  • Cellular localization

    Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links

  • Alternative names

    • Alanine/serine/cysteine/threonine transporter 1 antibody
    • ASCT-1 antibody
    • ASCT1 antibody
    • AW045657 antibody
    • Glutamate/neutral amino acid transporter antibody
    • Neutral amino acid transporter A antibody
    • OTTHUMP00000159933 antibody
    • OTTHUMP00000235138 antibody
    • SATT antibody
    • SATT_HUMAN antibody
    • SLC1A4 antibody
    • Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 antibody
    • Solute carrier family 1 member 4 antibody
    see all

Images

  • Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized A431 cells labeling ASCT-1 with ab204348 at 4 µg/ml (green).

  • Immunohistochemical analysis of paraffin-embedded Human oral mucosa tissue labeling ASCT-1 with ab204348 at 1/20 dilution.

References

ab204348 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab204348.
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