Overview

  • Product name
  • Description
    Rabbit polyclonal to ASGR2
  • Host species
    Rabbit
  • Specificity
    Ab37470 detects all three isoforms of Asialoglycoprotein Receptor.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human ASGR2.

  • General notes

    Previously labelled as Asialoglycoprotein Receptor 2.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab37470 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 4 µg/ml. Predicted molecular weight: 35 kDa.

Target

  • Function
    Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
  • Tissue specificity
    Expressed exclusively in hepatic parenchymal cells.
  • Sequence similarities
    Contains 1 C-type lectin domain.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ASGP R antibody
    • ASGP-R 2 antibody
    • ASGPR 2 antibody
    • ASGPR2 antibody
    • Asgr2 antibody
    • ASGR2_HUMAN antibody
    • Asialoglycoprotein receptor 2 antibody
    • C type lectin domain family 4 member H2 antibody
    • C-type lectin domain family 4 member H2 antibody
    • CLEC4H2 antibody
    • HBxAg-binding protein antibody
    • HBXBP antibody
    • Hepatic lectin 2 antibody
    • Hepatic lectin H2 antibody
    • Hepatic lectin R2/3 antibody
    • HL-2 antibody
    • Hs.1259 antibody
    • L H2 antibody
    • LH2 antibody
    • MGC108546 antibody
    • MHL 2 antibody
    • RHL2 antibody
    see all

References

This product has been referenced in:
  • Speicher T  et al. Knockdown and knockout of ß1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling. Nat Commun 5:3862 (2014). Read more (PubMed: 24844558) »
See 1 Publication for this product

Customer reviews and Q&As

1-3 of 3 Abreviews or Q&A

Answer

Thank you for contacting us. Because we carry over 95,000 products, it isn't feasible for us to keep small sample sizes of our products.

We are happy to reassure our customers that all of our products are covered by our Abpromise, which guarantees that the product will work in the applications and species specified on the datasheet, or we will offer a replacement, credit, or refund within 6 months of purchase.

If the product is to be used in an untested species or application, you may be eligible for our testing discount program if the antibody has not yet been purchased.

As with ab77032 I can also offer youto take part in our Abreviewtesting discount program for ab37470.

I personally would suggest to test ab77032 since this antibody was used in ELISA before.

Please contact our Scientific Support team by replying to this email prior to purchase for more information.

Otherwise, we like to encourage all of our customers to submit an Abreview via the online product datasheet. We always appreciate customer feedback, whether positive or negative, and we make all product information available to researchers. Plus, each Abreview earns Abpoints that can be used for discounts on future purchases or rewards such as Amazon.com gift certificates.

To find out more about our Abreview system, please see the following link:

https://www.abcam.com/abreviews

I hope this information is helpful. Please do not hesitate to contact us again with any other questions.

Read More
Abcam has not validated the combination of species/application used in this Abreview.
Application
Immunocytochemistry/ Immunofluorescence
Sample
Human Cell (HepG2)
Permeabilization
No
Specification
HepG2
Blocking step
Protein Block (serum free) as blocking agent for 20 minute(s) · Concentration: 100% · Temperature: 4°C
Fixative
Paraformaldehyde

Abcam user community

Verified customer

Submitted Oct 08 2008

Answer

Thank you for your enquiry and patience while I researched your inquiry. ab37470 will detect all three isoforms of Asialoglycoprotein Rec. 2. I have updated the datasheet to reflect this. To date this antibody has only been tested for application by western blotting and is yet to be tested for neutralising activity. Unfortunately the immunogen sequence for this antibody is commercially sensitive. I hope this information helps, please do not hesitate to contact us if you need any more advice or information.

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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