Overview

  • Product name

  • Description

    Rabbit polyclonal to ASIC2
  • Host species

    Rabbit
  • Specificity

    This antibody recognizes human ASIC2 isoform 2
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Mouse ASIC2 aa 15-26.
    Sequence:

    CSGPGRFMAREQ


    Database link: Q925H0-2

  • Positive control

    • IHC-P: Human brain, cerebellum tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab219814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 2.5 - 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
  • Tissue specificity

    Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
  • Sequence similarities

    Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN1 subfamily.
  • Cellular localization

    Cell membrane. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
  • Information by UniProt
  • Database links

  • Alternative names

    • ACCN antibody
    • ACCN1 antibody
    • ACCN1_HUMAN antibody
    • Acid sensing ion channel 2 antibody
    • Acid-sensing ion channel 2 antibody
    • Amiloride sensitive brain sodium channel antibody
    • Amiloride sensitive cation channel 1 neuronal (degenerin) antibody
    • Amiloride sensitive cation channel 1 neuronal antibody
    • Amiloride-sensitive brain sodium channel antibody
    • Amiloride-sensitive cation channel 1, neuronal antibody
    • Amiloride-sensitive cation channel neuronal 1 antibody
    • ASIC2 antibody
    • ASIC2a antibody
    • BNaC1 antibody
    • BNC1 antibody
    • Brain sodium channel 1 antibody
    • Degenerin antibody
    • hBNaC1 antibody
    • Mammalian degenerin homolog antibody
    • MDEG antibody
    • Neuronal amiloride sensitive cation channel 1 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded human cerebellum tissue sections labeling ASIC2 with ab219814 at 2.5 µg/mL.

References

ab219814 has not yet been referenced specifically in any publications.

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