Overview

  • Product name

    Anti-ASK1 antibody - C-terminal
    See all ASK1 primary antibodies
  • Description

    Rabbit polyclonal to ASK1 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within C terminal amino acids 978-1374 of Human ASK1 (Q99683).

  • Positive control

    • HeLa S3 whole cell lysate; Cal27 xenograft tissue; 293T, H1299 and Raji lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab137339 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 155 kDa.
IHC-P 1/100 - 1/1000. Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).

Target

  • Function

    Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.
  • Tissue specificity

    Abundantly expressed in heart and pancreas.
  • Sequence similarities

    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Dephosphorylated and activated by PGAM5.
  • Information by UniProt
  • Database links

  • Alternative names

    • Apoptosis signal regulating kinase 1 antibody
    • Apoptosis signal-regulating kinase 1 antibody
    • ASK 1 antibody
    • ASK-1 antibody
    • ASK1 antibody
    • M3K5 antibody
    • M3K5_HUMAN antibody
    • MAP/ERK kinase kinase 5 antibody
    • MAP3K5 antibody
    • MAPK/ERK kinase kinase 5 antibody
    • MAPKKK5 antibody
    • MEK kinase 5 antibody
    • MEKK 5 antibody
    • MEKK5 antibody
    • Mitogen activated protein kinase kinase kinase 5 antibody
    • Mitogen-activated protein kinase kinase kinase 5 antibody
    see all

Images

  • Anti-ASK1 antibody - C-terminal (ab137339) at 1/1000 dilution + HeLa S3 whole cell lysate at 30 µg

    Predicted band size: 155 kDa



    5% SDS PAGE
  • Immunohistochemical analysis of paraffin-embedded Cal27 xenograft labelling ASK1 with ab137339 at 1/500 dilution.

References

ab137339 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab137339.
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