Validated using a knockout cell line

Recombinant Anti-ASK1 antibody [EP553Y] (ab45178)

Publishing research using ab45178? Please let us know so that we can cite the reference in this datasheet.

ab45178 has been referenced in 17 publications.

  • Giuliano CJ  et al. MELK expression correlates with tumor mitotic activity but is not required for cancer growth. Elife 7:N/A (2018). PubMed: 29417930
  • Cheng R  et al. ß-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress. Biochim Biophys Acta Gen Subj 1862:2271-2280 (2018). PubMed: 30031111
  • Leestemaker Y  et al. Proteasome Activation by Small Molecules. Cell Chem Biol 24:725-736.e7 (2017). PubMed: 28552582
  • Ren X  et al. Protective function of pyridoxamine on retinal photoreceptor cells via activation of the p-Erk1/2/Nrf2/Trx/ASK1 signalling pathway in diabetic mice. Mol Med Rep 14:420-4 (2016). PubMed: 27177199
  • Hattori K  et al. ASK1 signalling regulates brown and beige adipocyte function. Nat Commun 7:11158 (2016). PubMed: 27045525
  • Luo Y  et al. ASK1 controls spindle orientation and positioning by phosphorylating EB1 and stabilizing astral microtubules. Cell Discov 2:16033 (2016). Human . PubMed: 27721984
  • Fujisawa T  et al. The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis. Hum Mol Genet 25:245-53 (2016). PubMed: 26604152
  • Watanabe T  et al. Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis. J Biol Chem 290:10791-803 (2015). PubMed: 25752609
  • Maruyama T  et al. Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses. Sci Signal 7:ra8 (2014). PubMed: 24448648
  • Mosallanejad K  et al. The DEAH-box RNA helicase DHX15 activates NF-?B and MAPK signaling downstream of MAVS during antiviral responses. Sci Signal 7:ra40 (2014). PubMed: 24782566
  • Zhang X  et al. Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet 94:547-58 (2014). PubMed: 24656866
  • Menon R  et al. Senescence of primary amniotic cells via oxidative DNA damage. PLoS One 8:e83416 (2013). WB ; Human . PubMed: 24386195
  • Kumar B  et al. Dynamics of physical interaction between HIV-1 Nef and ASK1: identifying the interacting motif(s). PLoS One 8:e67586 (2013). WB . PubMed: 23799149
  • Noh KT  et al. GSK-3ß-induced ASK1 stabilization is crucial in LPS-induced endotoxin shock. Exp Cell Res 317:1663-8 (2011). WB ; Mouse . PubMed: 21515258
  • Durgadoss L  et al. Redox modification of Akt mediated by the dopaminergic neurotoxin MPTP, in mouse midbrain, leads to down-regulation of pAkt. FASEB J : (2011). PubMed: 22198382
  • Roy S  et al. Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts. Cardiovasc Res 87:647-55 (2010). WB ; Mouse . PubMed: 20427335
  • Cekic C  et al. Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. J Biol Chem 284:31982-91 (2009). WB ; Mouse . PubMed: 19759006

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