Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity.
Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.
In the N-terminal section; belongs to the maf family.
Immunohistochemical analysis of formalin fixed and paraffin embedded Human colon tissue labeling ASMTL with ab171622 at 1/10 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot - Anti-ASMTL antibody (ab171622)
All lanes : Anti-ASMTL antibody (ab171622) at 1/100 dilution
Lane 1 : MDA-MB231 cell line lysate Lane 2 : HL-60 cell line lysate Lane 3 : Hela cell line lysate Lane 4 : A549 cell line lysate Lane 5 : CEM cell line lysate