Asperosaponin VI (Akebia Saponin D), triterpene saponin  (ab143574)

Overview

  • Product name

    Asperosaponin VI (Akebia Saponin D), triterpene saponin 
  • Description

    Anti-inflammatory, antioxidant agent
  • Alternative names

    • Akebia Saponin D
  • Biological description

    Anti-inflammatory, antioxidant agent. Inhibits Akt and IκB kinase phosphorylation and NF-κB activation. Lowers creatine kinase-MB, lactate dehydrogenase and glutamic oxaloacetic transaminase levels. Increases glutathione peroxidase and SOD levels. Attenuates amyloid-β cytotoxicity. Shows anti-ischemic and anti-inflammatory effects in vivo.
  • Purity

    > 98%
  • CAS Number

    39524-08-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Yu X  et al. Akebia Saponin D attenuates amyloid ß-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-?B pathway. Behav Brain Res 235:200-9 (2012). Read more (PubMed: 22963993) »
  • Li C  et al. Protective roles of Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall on acute myocardial infarction in rats. Eur J Pharmacol 627:235-41 (2010). Read more (PubMed: 19909736) »
  • Li C  et al. Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways. Eur J Pharmacol 649:100-7 (2010). Read more (PubMed: 20863824) »

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