Product nameAsperosaponin VI (Akebia Saponin D), triterpene saponin
DescriptionAnti-inflammatory, antioxidant agent
- Akebia Saponin D
Biological descriptionAnti-inflammatory, antioxidant agent. Inhibits Akt and IκB kinase phosphorylation and NF-κB activation. Lowers creatine kinase-MB, lactate dehydrogenase and glutamic oxaloacetic transaminase levels. Increases glutathione peroxidase and SOD levels. Attenuates amyloid-β cytotoxicity. Shows anti-ischemic and anti-inflammatory effects in vivo.
Chemical name[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-[[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (6aR,6aS,6bR,8aR,9R,10S,12aR,14bR)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-3,4,4a,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4-carboxylate
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal transduction
- Nitric oxide & oxidative stress
This product has been referenced in:
- Yu X et al. Akebia Saponin D attenuates amyloid ß-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-?B pathway. Behav Brain Res 235:200-9 (2012). Read more (PubMed: 22963993) »
- Li C et al. Protective roles of Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall on acute myocardial infarction in rats. Eur J Pharmacol 627:235-41 (2010). Read more (PubMed: 19909736) »
- Li C et al. Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways. Eur J Pharmacol 649:100-7 (2010). Read more (PubMed: 20863824) »