Overview

  • Product name

    Anti-Astrin/Deepest antibody
    See all Astrin/Deepest primary antibodies
  • Description

    Rabbit polyclonal to Astrin/Deepest
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Fusion protein corresponding to Human Astrin/Deepest (internal sequence). (BC000322).
    Database link: Q96R06

  • Positive control

    • Human liver cancer tissue.
  • General notes

     This product was previously labelled as Astrin

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab197338 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.

Target

  • Function

    Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.
  • Tissue specificity

    Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon.
  • Cellular localization

    Cytoplasm. Cytoplasm > cytoskeleton > spindle. Cytoplasm > cytoskeleton > spindle pole. Chromosome > centromere > kinetochore. In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Detected on kinetochores of chromosomes that have congressed. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends.
  • Information by UniProt
  • Database links

  • Alternative names

    • Astrin antibody
    • Deepest antibody
    • hMAP 126 antibody
    • hMAP126 antibody
    • MAP 126 antibody
    • MAP126 antibody
    • Mitotic spindle associated protein antibody
    • Mitotic spindle associated protein p126 antibody
    • Mitotic spindle coiled coil related protein antibody
    • Mitotic spindle-associated protein p126 antibody
    • SPAG 5 antibody
    • SPAG5 antibody
    • SPAG5_HUMAN antibody
    • Sperm associated antigen 5 antibody
    • Sperm tail protein Spag 5 antibody
    • Sperm tail protein Spag5 antibody
    • Sperm-associated antigen 5 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling Astrin/Deepest with ab197338 at 1/25 dilution.

References

ab197338 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab197338.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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