Key features and details
- Rabbit polyclonal to Astrin/Deepest
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Astrin/Deepest antibody
See all Astrin/Deepest primary antibodies
DescriptionRabbit polyclonal to Astrin/Deepest
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Fusion protein corresponding to Human Astrin/Deepest (internal sequence). (BC000322).
Database link: Q96R06
- Human liver cancer tissue.
This product was previously labelled as Astrin
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab197338 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/25 - 1/100.|
FunctionEssential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.
Tissue specificityHighly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon.
Cellular localizationCytoplasm. Cytoplasm > cytoskeleton > spindle. Cytoplasm > cytoskeleton > spindle pole. Chromosome > centromere > kinetochore. In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Detected on kinetochores of chromosomes that have congressed. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends.
- Information by UniProt
- Astrin antibody
- Deepest antibody
- hMAP 126 antibody
ab197338 has not yet been referenced specifically in any publications.