AT 101,  Bcl-2 and Mcl-1 inhibitor (BH3-mimetic) (ab145624)

Overview

  • Product name
    AT 101,  Bcl-2 and Mcl-1 inhibitor (BH3-mimetic)
  • Description
    Pro-apoptotic agent. BH3-mimetic. Bcl-2 and Mcl-1 inhibitor.
  • Biological description
    Pro-apoptotic agent. BH3-mimetic. Bcl-2 and Mcl-1 inhibitor. Gossypol (ab141050, ab144391) enantiomer. Induces Noxa and PUMA. Shows antiproliferative and chemosensitizing effects in vivo. Orally active.
  • Purity
    > 98%
  • CAS Number
    90141-22-3
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    (R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
  • Molecular weight
    518.56
  • Molecular formula
    C30H30O8
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 75 mM and in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    OC1=C(O)C(C(C)C)=C(C=C(C)C(C2=C(O)C(C(C([H])=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)=C4O)C4=C1C([H])=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Kaza N  et al. BNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells. PLoS One 9:e96733 (2014). Read more (PubMed: 24824755) »
  • Ren T  et al. Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. Drug Des Devel Ther 8:2517-29 (2014). Read more (PubMed: 25548514) »
  • Imai A  et al. Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects. Cancer Res 72:716-25 (2012). Read more (PubMed: 22158856) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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