• Product name
  • Description
    Rabbit polyclonal to AT11A
  • Host species
  • Specificity
    ab105351 is predicted to not cross react with AT11B. At least two isoforms of AT11A are known to exist; this antibody will recognize both.
  • Tested applications
    Suitable for: ICC/IF, WB, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 19 amino acid peptide from a region within the N terminus of Human AT11A (NP_115565).

  • Positive control
    • WB: K562 cell lysate ICC: K562 cells



Our Abpromise guarantee covers the use of ab105351 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 130 kDa.
ICC Use a concentration of 10 µg/ml.


  • Function
    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.
  • Sequence similarities
    Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
  • Cellular localization
    Cell membrane. Early endosome. Recycling endosome. Endoplasmic reticulum. Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.
  • Information by UniProt
  • Database links
  • Form
    P-type ATPases, such as ATP11A, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes.
  • Alternative names
    • AT11A_HUMAN antibody
    • Atp11a antibody
    • ATPase class VI type 11A antibody
    • ATPase IS antibody
    • ATPIH antibody
    • ATPIS antibody
    • P4-ATPase flippase complex alpha subunit ATP11A antibody
    • Probable phospholipid-transporting ATPase IH antibody
    see all


  • Immunofluorescence of ATP11A in K562 cells with ab105351 at 20 ug/mL.

  • All lanes : Anti-AT11A antibody (ab105351) at 1 µg/ml

    Lane 1 : K562 cell lysate
    Lane 2 : K562 cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 130 kDa

  • ab105351, at 10 µg/ml, staining AT11A in K562 cells by Immunocytochemistry.


ab105351 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for your reply and thank you for trying the mouse samples as well! I am very sorry that these3 antibodies did not perform as expected. I would be happy to offer you either a free of charge replacement for each antibody, or a credit or r...

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