Overview

  • Product name

    AT9283, pan-aurora kinase and JAK inhibitor
  • Description

    Potent, selective pan-aurora kinase and JAK inhibitor
  • Biological description

    Potent, selective pan-aurora kinase and JAK2/3 inhibitor (IC50 values are 1.1, 1.2, 3 and 3 nM for JAK3, JAK2 and Aurora A and B respectively). Induces apoptosis and inhibits proliferation. Shows antitumor effects in vivo.
  • Purity

    > 95%
  • CAS Number

    896466-04-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Qi W  et al. AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas. Int J Cancer 130:2997-3005 (2012). Read more (PubMed: 21796626) »
  • Santo L  et al. Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide. Clin Cancer Res 17:3259-71 (2011). Read more (PubMed: 21430070) »
  • Dawson MA  et al. AT9283, a potent inhibitor of the Aurora kinases and Jak2, has therapeutic potential in myeloproliferative disorders. Br J Haematol 150:46-57 (2010). Read more (PubMed: 20507304) »

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