Anti-ATG9B antibody (ab117591)
Key features and details
- Rabbit polyclonal to ATG9B
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ATG9B antibody
See all ATG9B primary antibodies -
Description
Rabbit polyclonal to ATG9B -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide conjugated to KLH from the C-terminus of Human ATG9B
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Positive control
- Human placenta tissue, Human spleen tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab117591 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 5 µg/ml.
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Notes |
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IHC-P
Use a concentration of 5 µg/ml. |
Target
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Function
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. -
Tissue specificity
Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial. -
Sequence similarities
Belongs to the ATG9 family. -
Cellular localization
Cytoplasmic vesicle, autophagosome membrane. Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1 and ATG13. - Information by UniProt
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Database links
- Entrez Gene: 285973 Human
- Entrez Gene: 213948 Mouse
- Entrez Gene: 499973 Rat
- Omim: 612205 Human
- SwissProt: Q674R7 Human
- SwissProt: Q6EBV9 Mouse
- Unigene: 707300 Human
- Unigene: 716846 Human
see all -
Alternative names
- APG9 like 2 antibody
- APG9-like 2 antibody
- Apg912 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (4)
ab117591 has been referenced in 4 publications.
- Liang W et al. Aging is associated with a decline in Atg9b-mediated autophagosome formation and appearance of enlarged mitochondria in the heart. Aging Cell 19:e13187 (2020). PubMed: 32627317
- Liao Y et al. Excessive ER-phagy mediated by the autophagy receptor FAM134B results in ER stress, the unfolded protein response, and cell death in HeLa cells. J Biol Chem 294:20009-20023 (2019). PubMed: 31748416
- Zhao R et al. Alliin alleviates myocardial ischemia-reperfusion injury by promoting autophagy. Biochem Biophys Res Commun 512:236-243 (2019). PubMed: 30885435
- Ma Z et al. The role ofCRPandATG9Bexpression in clear cell renal cell carcinoma. Biosci Rep 37:N/A (2017). PubMed: 28923830