Product nameATI-2341, CXCR4 chemokine receptor agonist
DescriptionAllosteric CXCR4 chemokine receptor agonist. Induces chemotaxis.
Allosteric, pepducin-based agonist of the CXCR4 receptor. Induces chemotoxis in cells expressing CXCR4. Induces intracellular calcium mobilization in endogenously CXCR4-expressing CCRF-CEM cells (EC50 = 194; Intrinsic activity = 81%). Induces CXCR4 receptor internalization. Effects of ATI-2341 are G-protein-dependent. In mouse models, ATI-2341 promotes peritoneal recruitment of PMNs following i.p. administration and increases PMNs in the peripheral circulation following i.v administration.
MGYQKKLRSMTDKYRL (Modifications: Met-1 = N-terminal palmitoyl)
SequenceMGYQKKLRSMTDKYRL (Modifications: Met-1 = N-terminal palmitoyl)
Storage instructionsShipped at 4°C. Store at -20°C. Store under desiccating conditions.
Soluble in DMSO to 50 mM
Soluble in ethanol to 0.9 mM
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab228571 has been referenced in 4 publications.
- Luo J et al. G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of ß-Arrestin. Mol Pharmacol 91:554-566 (2017). PubMed: 28331048
- Quoyer J et al. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A 110:E5088-97 (2013). PubMed: 24309376
- Janz JM et al. Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4. J Am Chem Soc 133:15878-81 (2011). PubMed: 21905700
- Tchernychev B et al. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc Natl Acad Sci U S A 107:22255-9 (2010). PubMed: 21139054