ATI-2341, CXCR4 chemokine receptor agonist (ab228571)

Overview

  • Product name

    ATI-2341, CXCR4 chemokine receptor agonist
  • Description

    Allosteric CXCR4 chemokine receptor agonist. Induces chemotaxis.
  • Biological description

    Allosteric, pepducin-based agonist of the CXCR4 receptor. Induces chemotoxis in cells expressing CXCR4. Induces intracellular calcium mobilization in endogenously CXCR4-expressing CCRF-CEM cells (EC50 = 194; Intrinsic activity = 81%). Induces CXCR4 receptor internalization. Effects of ATI-2341 are G-protein-dependent. In mouse models, ATI-2341 promotes peritoneal recruitment of PMNs following i.p. administration and increases PMNs in the peripheral circulation following i.v administration.

  • Purity

    > 96%
  • CAS Number

    1337878-62-2

Properties

  • Chemical name

    MGYQKKLRSMTDKYRL (Modifications: Met-1 = N-terminal palmitoyl)


    L-Leucine, N-(1-oxohexadecyl)-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-


     

  • Molecular weight

    2256.82
  • Molecular formula

    C104H178N26O25S2
  • Sequence

    MGYQKKLRSMTDKYRL (Modifications: Met-1 = N-terminal palmitoyl)
  • PubChem identifier

    101961246
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 50 mM

    Soluble in ethanol to 0.9 mM

  • Source

    Synthetic

References

ab228571 has not yet been referenced specifically in any publications.

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