Atomoxetine Hydrochloride (Tomoxetine hydrochloride), norepinephrine reuptake inhibitor (ab144699)

Overview

  • Product name

    Atomoxetine Hydrochloride (Tomoxetine hydrochloride), norepinephrine reuptake inhibitor
  • Description

    Potent, selective, competitive norepinephrine reuptake inhibitor
  • Biological description

    Potent, selective, competitive norepinephrine reuptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Decreases glutamatergic transmission in a brain region-specific manner. Shows psychostimulant and appetite suppressant effects in vivo. Blood-brain barrier permeable. Orally active.
  • CAS Number

    82857-40-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride
  • Molecular weight

    291.82
  • Molecular formula

    C17H21NO.HCl
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.Cc2ccccc2OC(CCNC)c1ccccc1
  • Source

    Synthetic

References

This product has been referenced in:

  • Chou D  et al. Brain-derived neurotrophic factor in the amygdala mediates susceptibility to fear conditioning. Exp Neurol 255:19-29 (2014). Read more (PubMed: 24582917) »
  • Navarra RL  et al. Methylphenidate and atomoxetine enhance sensory-evoked neuronal activity in the visual thalamus of male rats. Exp Clin Psychopharmacol 21:363-74 (2013). Read more (PubMed: 24099357) »
  • Udvardi PT  et al. Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain--an in vivo study. Drug Des Devel Ther 7:1433-46 (2013). Read more (PubMed: 24348020) »

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