Atorvastatin hemicalcium salt, HMG-CoA reductase inhibitor (ab141083)

Overview

  • Product name

    Atorvastatin hemicalcium salt, HMG-CoA reductase inhibitor
  • Description

    Potent HMG-CoA reductase inhibitor
  • Biological description

    Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Metabolised by CYP3A4. Able to reduce circulating LDL-C through inhibition of cholesterol biosynthesis and inducing expression of LDL receptors.
  • Purity

    > 99%
  • CAS Number

    134523-03-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    RR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt
  • Molecular weight

    577.68
  • Molecular formula

    C33H34FN2O5.0.5Ca
  • PubChem identifier

    60822
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [Ca+2].O[C@H](CCn1c(c(c(c1C(C)C)C(=O)Nc2ccccc2)c3ccccc3)c4ccc(F)cc4)C[C@@H](O)CC([O-])=O.[O-]C(=O)C[C@H](O)C[C@H](O)CCn4c(c1ccc(F)cc1)c(c2ccccc2)c(C(=O)Nc3ccccc3)c4C(C)C
  • Source

    Synthetic

  • Research areas

Applications

Our Abpromise guarantee covers the use of ab141083 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • ab90529 staining cytochrome C in HepG2 cells treated with atorvastatin hemicalcium salt (ab141083), by ICC/IF. Increase of cytochrome C expression correlates with increased concentration of atorvastatin hemicalcium salt, as described in literature.
    The cells were incubated at 37°C for 4 hours in media containing different concentrations of ab141083 (atorvastatin hemicalcium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab90529 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

References

This product has been referenced in:

  • Turner NA  et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol 50:458-61 (2007). Read more (PubMed: 18049315) »
  • Istvan ES & Deisenhofer J Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292:1160-4 (2001). Read more (PubMed: 11349148) »
  • Dansette PM  et al. HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. Exp Toxicol Pathol 52:145-8 (2000). Read more (PubMed: 10965989) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141083.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up