Overview

  • Product name

    Atovaquone, Antiparasitic agent
  • Description

    Broad-spectrum antiparasitic agent. Ubiquinone analog.
  • Biological description

    Antiparasitic agent. Protozoan ubiquinone (ab143173) analog. Inhibits coenzyme Q-complex III binding at the Qo cytochrome domain. Disrupts the protozoa electron transport chain. Active against Plasmodium spp., P. carinii, Babesia spp., and Toxoplasma gondii in vivo. Orally active.
  • CAS Number

    95233-18-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
  • Molecular weight

    366.84
  • Molecular formula

    C22H19ClO3
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Clc1ccc(cc1)[C@@H]2CC[C@H](CC2)C=4C(=O)c3ccccc3C(=O)C=4O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Karaman R  et al. Computationally designed atovaquone prodrugs based on Bruice's enzyme model. Curr Comput Aided Drug Des 10:15-27 (2014). Read more (PubMed: 24138416) »
  • Tanabe K  et al. Plasmodium falciparum mitochondrial genetic diversity exhibits isolation-by-distance patterns supporting a sub-Saharan African origin. Mitochondrion 13:630-6 (2013). Read more (PubMed: 24004956) »
  • Iguchi A  et al. The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs. Vet Parasitol 197:527-33 (2013). Read more (PubMed: 24075418) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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