Key features and details
- Rabbit polyclonal to ATP-binding cassette sub-family A member 3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-ATP-binding cassette sub-family A member 3 antibody
See all ATP-binding cassette sub-family A member 3 primary antibodies
DescriptionRabbit polyclonal to ATP-binding cassette sub-family A member 3
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human ATP-binding cassette sub-family A member 3 aa 43-203.
RLKIQSENVPNATIYPGQSIQELPLFFTFPPPGDTWELAYIPSHSDAAKT VTETVRRALVINMRVRGFPSEKDFEDYIRYDNCSSSVLAAVVFEHPFNHS KEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWHTTSLFPLFPNPG PREPTSPDGGE
Database link: Q99758
- IHC-P: Human lung and testis tissues.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab229761 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/20 - 1/200.|
FunctionPlays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.
Tissue specificityHighly expressed in lung, followed by brain, pancreas, skeletal muscle and heart. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma.
Involvement in diseaseDefects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3) [MIM:610921]; also called pulmonary alveolar proteinosis due to ABCA3 deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Sequence similaritiesBelongs to the ABC transporter superfamily. ABCA family.
Contains 2 ABC transporter domains.
DomainMultifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
- Information by UniProt
- ABC 3 antibody
- ABC C antibody
- ABC C transporter antibody
Paraffin-embedded human lung tissue stained for ATP-binding cassette sub-family A member 3 using ab229761 at 1/100 dilution in immunohistochemical analysis.
Paraffin-embedded human testis tissue stained for ATP-binding cassette sub-family A member 3 using ab229761 at 1/100 dilution in immunohistochemical analysis.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab229761 has not yet been referenced specifically in any publications.