Product nameAnti-ATP1A2 antibody [EPR11896(B)]
See all ATP1A2 primary antibodies
DescriptionRabbit monoclonal [EPR11896(B)] to ATP1A2
Tested applicationsSuitable for: WBmore details
Unsuitable for: ICC/IF,IHC-P or IP
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide corresponding to residues in Human ATP1A2 (P50993).
- Human skeletal muscle and fetal heart lysates
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab166888 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000 - 1/5000. Detects a band of approximately 102 kDa (predicted molecular weight: 112 kDa).|
FunctionThis is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
Involvement in diseaseDefects in ATP1A2 are the cause of migraine familial hemiplegic type 2 (FHM2) [MIM:602481]. FHM2 is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis.
Defects in ATP1A2 are a cause of alternating hemiplegia of childhood (AHC) [MIM:104290]. AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age.
Sequence similaritiesBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Cellular localizationMembrane. Cell membrane.
- Information by UniProt
- AT1A2_HUMAN antibody
- Atp1a2 antibody
- FHM2 antibody
All lanes : Anti-ATP1A2 antibody [EPR11896(B)] (ab166888) at 1/1000 dilution
Lane 1 : Human skeletal
Lane 2 : Fetal heart lysate
Lysates/proteins at 10 µg per lane.
All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 112 kDa
Observed band size: 102 kDa why is the actual band size different from the predicted?
ab166888 has not yet been referenced specifically in any publications.