Overview

  • Product name

    Anti-ATP1A2 antibody [EPR11896(B)]
    See all ATP1A2 primary antibodies
  • Description

    Rabbit monoclonal [EPR11896(B)] to ATP1A2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: ICC/IF,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human ATP1A2 (P50993).

  • Positive control

    • Human skeletal muscle and fetal heart lysates
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab166888 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Detects a band of approximately 102 kDa (predicted molecular weight: 112 kDa).
  • Application notes
    Is unsuitable for ICC/IF,IHC-P or IP.
  • Target

    • Function

      This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
    • Involvement in disease

      Defects in ATP1A2 are the cause of migraine familial hemiplegic type 2 (FHM2) [MIM:602481]. FHM2 is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis.
      Defects in ATP1A2 are a cause of alternating hemiplegia of childhood (AHC) [MIM:104290]. AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age.
    • Sequence similarities

      Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
    • Cellular localization

      Membrane. Cell membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • AT1A2_HUMAN antibody
      • Atp1a2 antibody
      • FHM2 antibody
      • KIAA0778 antibody
      • MHP2 antibody
      • Na(+)/K(+) ATPase alpha-2 subunit antibody
      • Na+/K+ ATPase alpha 2 subunit antibody
      • Sodium potassium ATPase antibody
      • Sodium pump subunit alpha 2 antibody
      • Sodium pump subunit alpha-2 antibody
      • Sodium/potassium transporting ATPase alpha 2 chain antibody
      • Sodium/potassium transporting ATPase subunit alpha 2 antibody
      • Sodium/potassium-transporting ATPase subunit alpha-2 antibody
      see all

    Images

    • All lanes : Anti-ATP1A2 antibody [EPR11896(B)] (ab166888) at 1/1000 dilution

      Lane 1 : Human skeletal
      muscle lysate
      Lane 2 : Fetal heart lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 112 kDa
      Observed band size: 102 kDa
      why is the actual band size different from the predicted?

    References

    ab166888 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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