Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferpH: 7.20
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab167509 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 101 kDa.|
|ICC/IF||Use a concentration of 10 µg/ml.|
FunctionThis magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Tissue specificityFound in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney.
Involvement in diseaseDefects in ATP2C1 are the cause of Hailey-Hailey disease (HHD) [MIM:169600]; also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD.
Sequence similaritiesBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
Cellular localizationGolgi apparatus membrane.
- Information by UniProt
- 1700121J11Rik antibody
- AT2C1_HUMAN antibody
- ATP dependent Ca(2+) pump PMR1 antibody
All lanes : Anti-ATP2C1 antibody (ab167509) at 1 µg/ml
Lane 1 : ATP2C1 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 15 µl per lane.
All lanes : Goat anti-Mouse IgG HRP at 1/2500 dilution
Predicted band size: 101 kDa
Immunofluorescent analysis of HeLa cells labeling ATP2C1 with ab167509 at 10 µg/ml.
ab167509 has not yet been referenced specifically in any publications.