Overview

  • Product name

  • Description

    Rabbit polyclonal to ATP2C1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human ATP2C1 aa 491-605.
    Database link: P98194

  • Positive control

    • IHC-P: Human brain tissue. ICC/IF: HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab238487 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
ICC/IF 1/50 - 1/200.

Target

  • Function

    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
  • Tissue specificity

    Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney.
  • Involvement in disease

    Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD) [MIM:169600]; also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD.
  • Sequence similarities

    Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
  • Cellular localization

    Golgi apparatus membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1700121J11Rik antibody
    • AT2C1_HUMAN antibody
    • ATP dependent Ca(2+) pump PMR1 antibody
    • ATP-dependent Ca(2+) pump PMR1 antibody
    • ATP2C1 antibody
    • ATP2C1A antibody
    • ATPase 2C1 antibody
    • ATPase Ca(2+) sequestering antibody
    • ATPase Ca++ transporting type 2C member 1 antibody
    • AW061228 antibody
    • BCPM antibody
    • Calcium transporting ATPase type 2C member 1 antibody
    • Calcium-transporting ATPase type 2C member 1 antibody
    • D930003G21Rik antibody
    • HHD antibody
    • hSPCA1 antibody
    • HUSSY 28 antibody
    • KIAA1347 antibody
    • MGC58010 antibody
    • MGC93231 antibody
    • OTTHUMP00000216066 antibody
    • OTTHUMP00000216068 antibody
    • OTTHUMP00000216069 antibody
    • OTTHUMP00000216071 antibody
    • OTTHUMP00000216072 antibody
    • OTTHUMP00000216073 antibody
    • OTTHUMP00000216074 antibody
    • OTTHUMP00000216075 antibody
    • PMR1 antibody
    • PMR1, rat, homolog of antibody
    • PMR1L antibody
    • Secretory pathway Ca(2+) ATPase 1 antibody
    • Secretory pathway Ca(2+)-transporting ATPase antibody
    • Secretory pathway Ca2+/Mn2+ ATPase 1 antibody
    • SPCA antibody
    • SPCA1 antibody
    see all

Images

  • Paraffin-embedded human brain tissue stained for ATP2C1 using ab238487 at 1/100 dilution in immunohistochemical analysis.

  • HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for ATP2C1 (green) using ab238487 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

References

ab238487 has not yet been referenced specifically in any publications.

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