• Product name

  • Description

    Rabbit polyclonal to ATP6V0A2
  • Host species

  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment corresponding to a region within amino acids 156-404 of Human ATP6V0A2 (NP_036595).

  • Positive control

    • 293T, A431 and H1299 whole cell lysates; DLD1 xenograft; HeLa, HepG2, MOLT4 and Raji cell lysates



Our Abpromise guarantee covers the use of ab96803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 98 kDa.
IHC-P 1/100 - 1/500.


  • Function

    Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH.
  • Involvement in disease

    Defects in ATP6V0A2 are the cause of cutis laxa autosomal recessive type 2A (ARCL2A) [MIM:219200]. An autosomal recessive disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral fissures, a general connective tissue weakness, and varying degrees of growth and developmental delay and neurological abnormalities. Some affected individuals develop seizures and mental deterioration later in life, whereas the skin phenotype tends to become milder with age. At the molecular level, an abnormal glycosylation of serum proteins is observed in many cases.
    Defects in ATP6V0A2 are a cause of wrinkly skin syndrome (WSS) [MIM:278250]. WSS is rare autosomal recessive disorder characterized by wrinkling of the skin of the dorsum of the hands and feet, an increased number of palmar and plantar creases, wrinkled abdominal skin, multiple musculoskeletal abnormalities, microcephaly, growth failure and developmental delay.
  • Sequence similarities

    Belongs to the V-ATPase 116 kDa subunit family.
  • Post-translational

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cell membrane. Endosome membrane. In kidney proximal tubules, also detected in subapical vesicles.
  • Information by UniProt
  • Database links

  • Alternative names

    • a2 antibody
    • A2V ATPase antibody
    • ARCL antibody
    • ATP6a2 antibody
    • ATP6N1D antibody
    • ATP6V0A2 antibody
    • ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 antibody
    • ATPase, H+ transporting, lysosomal V0 subunit a2 antibody
    • Infantile malignant osteopetrosis antibody
    • J6B7 antibody
    • Lysosomal H(+) transporting ATPase V0 subunit a2 antibody
    • Lysosomal H(+)-transporting ATPase V0 subunit a2 antibody
    • regeneration and tolerance factor antibody
    • Stv1 antibody
    • TJ6 antibody
    • TJ6M antibody
    • TJ6s antibody
    • V ATPase 116 kDa isoform a2 antibody
    • V type proton ATPase 116 kDa subunit a antibody
    • V type proton ATPase 116 kDa subunit a isoform 2 antibody
    • V-ATPase 116 kDa isoform a2 antibody
    • V-type proton ATPase 116 kDa subunit a isoform 2 antibody
    • Vacuolar proton translocating ATPase 116 kDa subunit a antibody
    • Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 antibody
    • Vph1 antibody
    • VPP2_HUMAN antibody
    • WSS antibody
    see all


  • All lanes : Anti-ATP6V0A2 antibody (ab96803) at 1/10000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate
    Lane 3 : H1299 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 98 kDa

    7.5% SDS PAGE
  • ab96803, at 1/500 dilution, staining ATP6V0A2 in paraffin-embedded DLD1 xenograft by Immunohistochemistry.


This product has been referenced in:

  • Kissing S  et al. Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes. Autophagy 13:670-685 (2017). Read more (PubMed: 28129027) »
  • Tripathi M  et al. Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Cell Death Dis 7:e2513 (2016). Read more (PubMed: 27929536) »
See all 3 Publications for this product

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