Key features and details
- Rabbit polyclonal to ATP6V0C
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-ATP6V0C antibody
See all ATP6V0C primary antibodies
DescriptionRabbit polyclonal to ATP6V0C
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Rat, Sheep, Rabbit, Horse, Cow, Dog
- OVCAR3 cell lysate This antibody gave a positive result when used in the following formaldehyde fixed cell lines: MCF-7.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 2% Sucrose, PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab104374 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 16 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.|
RelevanceATP6V0C is a component of the V0 domain (proton pore complex) of vacuolar ATPase (V-ATPase). Vacuolar ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.
Cellular localizationVacuole membrane; Multi-pass membrane protein.
- ATP6C antibody
- ATP6L antibody
- ATPase, H+ transporting, lysosomal, V0 subunit c antibody
ab104374 has been referenced in 3 publications.
- Xu Y et al. A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy. Cell 178:552-566.e20 (2019). PubMed: 31327526
- Kim BK et al. Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer. Br J Cancer 119:1347-1357 (2018). PubMed: 30420612
- Milkereit R et al. LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation. Nat Commun 6:7250 (2015). PubMed: 25998567