• Product name

  • Description

    Rabbit polyclonal to ATP7b
  • Host species

  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide from the N-Terminus of Human ATP7b.

  • Positive control

    • Human lung (respiratory epithelium) tissue or HeLa cells.



Our Abpromise guarantee covers the use of ab133731 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.


  • Function

    Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
  • Tissue specificity

    Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues.
  • Involvement in disease

    Defects in ATP7B are the cause of Wilson disease (WD) [MIM:277900]. WD is an autosomal recessive disorder of copper metabolism in which copper cannot be incorporated into ceruloplasmin in liver, and cannot be excreted from the liver into the bile. Copper accumulates in the liver and subsequently in the brain and kidney. The disease is characterized by neurologic manifestations and signs of cirrhosis.
  • Sequence similarities

    Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
    Contains 6 HMA domains.
  • Post-translational

    Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form.
  • Cellular localization

    Cytoplasm; Mitochondrion and Golgi apparatus > trans-Golgi network membrane. Predominantly found in the trans-Golgi network (TGN). Not redistributed to the plasma membrane in response to elevated copper levels.
  • Information by UniProt
  • Database links

  • Alternative names

    • ATP7B antibody
    • ATP7B_HUMAN antibody
    • ATPase, Cu(2+) transporting, beta polypeptide antibody
    • ATPase, Cu++ transporting, beta polypeptide antibody
    • Copper pump 2 antibody
    • Copper transporting ATPase 2 antibody
    • PWD antibody
    • Toxic milk antibody
    • tx antibody
    • WC1 antibody
    • WD antibody
    • Wilson disease associated protein antibody
    • Wilson disease-associated protein antibody
    • WND antibody
    • WND/140 kDa antibody
    see all


  • Immunohistochemical analysis of formalin-fixed, paraffin embedded Human lung (respiratory epithelium) tissue labelling ATP7b with ab133731 at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Immunofluorescence analysis of HeLa cells, labelling ATP7b with ab133731 at a 1/100 dilution (left image), or immunizing peptide (right image).


ab133731 has not yet been referenced specifically in any publications.

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