Recombinant
RabMAb

Recombinant Anti-ATP7b antibody [EPR6793] - BSA and Azide free (ab240049)

Overview

  • Product name

    Anti-ATP7b antibody [EPR6793] - BSA and Azide free
    See all ATP7b primary antibodies
  • Description

    Rabbit monoclonal [EPR6793] to ATP7b - BSA and Azide free
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human ATP7b aa 150-250. The exact sequence is proprietary.

  • General notes

    ab240049 is the carrier-free version of ab131208 This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.

     

    Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.

    Use our conjugation kits  for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    Ab240049 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.

    Maxpar® is a trademark of Fluidigm Canada Inc.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab240049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 157 kDa.

Target

  • Function

    Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
  • Tissue specificity

    Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues.
  • Involvement in disease

    Defects in ATP7B are the cause of Wilson disease (WD) [MIM:277900]. WD is an autosomal recessive disorder of copper metabolism in which copper cannot be incorporated into ceruloplasmin in liver, and cannot be excreted from the liver into the bile. Copper accumulates in the liver and subsequently in the brain and kidney. The disease is characterized by neurologic manifestations and signs of cirrhosis.
  • Sequence similarities

    Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
    Contains 6 HMA domains.
  • Post-translational
    modifications

    Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form.
  • Cellular localization

    Cytoplasm; Mitochondrion and Golgi apparatus > trans-Golgi network membrane. Predominantly found in the trans-Golgi network (TGN). Not redistributed to the plasma membrane in response to elevated copper levels.
  • Information by UniProt
  • Database links

  • Alternative names

    • ATP7B antibody
    • ATP7B_HUMAN antibody
    • ATPase, Cu(2+) transporting, beta polypeptide antibody
    • ATPase, Cu++ transporting, beta polypeptide antibody
    • Copper pump 2 antibody
    • Copper transporting ATPase 2 antibody
    • PWD antibody
    • Toxic milk antibody
    • tx antibody
    • WC1 antibody
    • WD antibody
    • Wilson disease associated protein antibody
    • Wilson disease-associated protein antibody
    • WND antibody
    • WND/140 kDa antibody
    see all

Images

  • Equilibrium disassociation constant (KD)
    Learn more about KD

    Click here to learn more about KD

    This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab131208).

References

ab240049 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab240049.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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