Key features and details
- Highly selective, potent ubiquinone-binding site mitochondrial complex II inhibitor
- CAS Number: 119509-24-9
- Purity: > 95%
- Soluble in ethanol and in DMSO
- Form / State: Solid
- Source: Synthetic
Product nameAtpenin A5, ubiquinone-binding site mitochondrial complex II inhibitor
DescriptionHighly selective, potent ubiquinone-binding site mitochondrial complex II inhibitor
Biological descriptionHighly selective, potent ubiquinone-binding site mitochondrial complex II inhibitor (IC50 values are 12 and 3.7 nM for nematode and mammalian mitochondria respectively). Stimulates mitochondrial KATP channels. Shows anti-ischemic and cardioprotective effects in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol and in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144194 has been referenced in 1 publication.
- Yancey DM et al. Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload. Am J Physiol Heart Circ Physiol 308:H651-63 (2015). IHC-P ; Rat . PubMed: 25599572