Atpenin A5, ubiquinone-binding site mitochondrial complex II inhibitor (ab144194)

Overview

  • Product name

    Atpenin A5, ubiquinone-binding site mitochondrial complex II inhibitor
  • Description

    Highly selective, potent ubiquinone-binding site mitochondrial complex II inhibitor
  • Biological description

    Highly selective, potent ubiquinone-binding site mitochondrial complex II inhibitor (IC50 values are 12 and 3.7 nM for nematode and mammalian mitochondria respectively). Stimulates mitochondrial KATP channels. Shows anti-ischemic and cardioprotective effects in vivo.
  • Purity

    > 95%
  • CAS Number

    119509-24-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethylhexanoyl]-4-hydroxy-5,6-dimethoxy-1H-pyridin-2-one
  • Molecular weight

    366.24
  • Molecular formula

    C15H21Cl2NO5
  • PubChem identifier

    54676868
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H](C[C@H](C)C(=O)C1=C(C(=C(NC1=O)OC)OC)O)[C@H](CCl)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Goncalves RL  et al. Sources of superoxide/H2O2 during mitochondrial proline oxidation. Redox Biol 2:901-9 (2014). Read more (PubMed: 25184115) »
  • Quinlan CL  et al. Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions. J Biol Chem 287:27255-64 (2012). Read more (PubMed: 22689576) »
  • Wojtovich AP  et al. The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria. Acta Biochim Pol 57:431-4 (2010). Read more (PubMed: 21103454) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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