Overview

  • Product name

    Atropine, mAChR antagonist
  • Description

    Potent, competitive, non-selective mAChR antagonist
  • Biological description

    Potent, competitive, non-selective mAChR antagonist (IC50 = 2.5 nM). Induces mydriasis. Shows antimuscarinic and anticholinergic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    51-55-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (8-Methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate
  • Molecular weight

    289.37
  • Molecular formula

    C17H23NO3
  • PubChem identifier

    3661
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
  • Source

    Solanaceae sp.

  • Research areas

References

This product has been referenced in:

  • Rocha BA  et al. CRLI induces vascular smooth muscle relaxation and suggests a dual mechanism of eNOS activation by legume lectins via muscarinic receptors and shear stress. Arch Biochem Biophys 565:32-9 (2015). Read more (PubMed: 25444858) »
  • Yang L  et al. Alpha2-adrenoceptor-independent inhibition of acetylcholine receptor channel and sodium channel by dexmedetomidine in rat superior cervical ganglion neurons. Neuroscience 289C:9-18 (2015). Read more (PubMed: 25583636) »
  • da Graça JR  et al. Subtotal nephrectomy inhibits the gastric emptying of liquid in awake rats. Physiol Rep 3: (2015). Read more (PubMed: 25677547) »
See 1 Publication for this product

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