Key features and details
- Potent, competitive, non-selective mAChR antagonist
- CAS Number: 51-55-8
- Purity: > 98%
- Soluble in water to 5 mM
- Form / State: Solid
- Source: Solanaceae sp.
Product nameAtropine, mAChR antagonist
DescriptionPotent, competitive, non-selective mAChR antagonist
Biological descriptionPotent, competitive, non-selective mAChR antagonist (IC50 = 2.5 nM). Induces mydriasis. Shows antimuscarinic and anticholinergic effects in vivo. Orally active.
Chemical name(8-Methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 5 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145582 has been referenced in 3 publications.
- Huang H et al. M1 Macrophage Activated by Notch Signal Pathway Contributed to Ventilator-Induced Lung Injury in Chronic Obstructive Pulmonary Disease Model. J Surg Res 244:358-367 (2019). PubMed: 31323391
- Radzicki D et al. Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain. J Neurosci 37:2292-2304 (2017). PubMed: 28137966
- Wang YJ et al. The Analgesic Effects of (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain. Anesth Analg 124:1330-1338 (2017). PubMed: 28002166