Key features and details
- Organic gold compound. Anti-inflammatory and antiproliferative agent.
- CAS Number: 34031-32-8
- Purity: > 98%
- Soluble in DMSO to 100 mM and ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameAuranofin, inhibits both leukocyte activation pathways
DescriptionOrganic gold compound. Anti-inflammatory and antiproliferative agent.
Organic gold compound. Anti-inflammatory and antiproliferative agent. Glutathione S-transferase P1-1 inhibitor (IC50 = 33 μM). Shows antiproliferative effects through STAT3 inhibition. Shows anti-inflammatory effects in vivo. Orally active.
Chemical name[1-(Thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold
Storage instructionsStore at Room Temperature. It is important to note that this product is reported to be light sensitive. Store In the Dark.
Solubility overviewSoluble in DMSO to 100 mM and ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141509 has been referenced in 2 publications.
- Hegazy AM et al. Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance. J Biol Chem 291:21496-21509 (2016). PubMed: 27519418
- Chen X et al. Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway. PLoS One 11:e0166386 (2016). PubMed: 27846303