Overview

  • Product name

    Auraptene, Activates PPARalpha and PPARgamma
  • Description

    Activates PPARα and PPARγ. Modulates estrogen receptors
  • Biological description

    Activates PPARα and PPARγ. Inhibits acyl-CoA:cholesterol acyl transferase (ACAT). Modulates estrogen receptors and disrupts ERK1/2-mediated phosphorylation of 4EBP1 and eIF4B. Chemopreventive properties. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    495-02-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • de Medina P  et al. Auraptene is an inhibitor of cholesterol esterification and a modulator of estrogen receptors. Mol Pharmacol 78:827-36 (2010). Read more (PubMed: 20702762) »
  • Kuroyanagi K  et al. Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes. Biochem Biophys Res Commun 366:219-25 (2008). Read more (PubMed: 18060855) »
  • Kawabata K  et al. Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism. FEBS Lett 580:5288-94 (2006). Read more (PubMed: 16979634) »

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