Overview

  • Product name

    Aureothin, TrxR1 inhibitor
  • Description

    TrxR1 inhibitor. Broad spectrum antibiotic agent.
  • Biological description

    TrxR1 inhibitor. Broad spectrum antibiotic agent. Antiproliferative agent. Shows antitumor, antifungal, insecticidal, antibacterial and antiparasitic effects in vivo.
  • Purity

    > 96%
  • CAS Number

    2825-00-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Methoxy-3,5-dimethyl-6-[(2R,5Z)-5-[(E)-2-methyl-3-(4-nitrophenyl)prop-2-enylidene]oxolan-2-yl]pyran-4-one
  • Molecular weight

    397.43
  • Molecular formula

    C22H23NO6
  • PubChem identifier

    6436188
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(OC(=C(C1=O)C)OC)[C@H]2CC/C(=C/C(=C/C3=CC=C(C=C3)[N+](=O)[O-])/C)/O2
  • Source

    Streptomyces thioluteus

References

This product has been referenced in:

  • Sugimoto Y  et al. Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line. Angew Chem Int Ed Engl 53:1560-4 (2014). Read more (PubMed: 24402879) »
  • Cochrane RV & Vederas JC Highly selective but multifunctional oxygenases in secondary metabolism. Acc Chem Res 47:3148-61 (2014). Read more (PubMed: 25250512) »
  • Werneburg M  et al. Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. J Am Chem Soc 132:10407-13 (2010). Read more (PubMed: 20662518) »

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