Overview

  • Product name

    Anti-Avian Influenza A Neuraminidase antibody - N-terminal
    See all Avian Influenza A Neuraminidase primary antibodies
  • Description

    Rabbit polyclonal to Avian Influenza A Neuraminidase - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ELISAmore details
  • Species reactivity

    Reacts with: Influenza A
  • Immunogen

    Synthetic peptide corresponding to Avian Influenza A Neuraminidase (N terminal). (11 amino acid peptide from near the amino terminus of the H7N9 [Influenza A virus (A/Shanghai/02/2013(H7N9))] Neuraminidase protein).
    Database link: AGL44440

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab191862 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 1 µg/ml.

Target

  • Relevance

    Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
  • Cellular localization

    Cell Membrane; Virion membrane. Apical cell membrane; Single-pass type II membrane protein (By similarity).
  • Database links

    • Alternative names

      • NA antibody
      • Neuraminidase antibody

    Images

    • ab191862 at 1 µg/ml detects 10 ng of H7N9 [Influenza A virus (A/Shanghai/02/2013(H7N9))] Neuraminidase peptide, and not 10 ng of H7N9 [Influenza A virus (A/blue-winged teal/Ohio/566/2006(H7N9))] Neuraminidase peptide in ELISA.

    References

    ab191862 has not yet been referenced specifically in any publications.

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