Product nameAvian Influenza A Nonstructural 1 peptide
Our Abpromise guarantee covers the use of ab51477 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Avian Influenza A Nonstructural 1 antibody (ab45417)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.12% Monobasic dihydrogen sodium phosphate, 0.142% Dibasic monohydrogen sodium phosphate, 0.164% Sodium phosphate, 0.754% Sodium chloride, 0.1% BSA
- Nonstructural protein 1
RelevanceInhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus.
Cellular localizationIn uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, and a fraction of NS1 is exported in the cytoplasm
ab51477 has not yet been referenced specifically in any publications.