Anti-AVPR V2 antibody (ab176488)
- Datasheet
- References
- Protocols
Overview
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Product nameAnti-AVPR V2 antibody
See all AVPR V2 primary antibodies -
DescriptionRabbit polyclonal to AVPR V2
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Host speciesRabbit
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Tested applicationsSuitable for: WB, ELISAmore details
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Species reactivityReacts with: Mouse, Rat, Human
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Immunogen
Synthetic peptide within Rat AVPR V2 (N terminal). The exact sequence is proprietary.
Database link: Q00788 -
Positive control
- Rat kidney extract.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
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Storage bufferPreservative: 0.09% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading... -
PurityImmunogen affinity purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab176488 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use at an assay dependent concentration. Detects a band of approximately 50 kDa (predicted molecular weight: 41 kDa). | |
| ELISA | Use at an assay dependent concentration. (cellular and membrane) |
Target
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FunctionReceptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
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Tissue specificityKidney.
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Involvement in diseaseDefects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]. This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis.
Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI) [MIM:304800]; also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. -
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
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Cellular localizationCell membrane.
- Information by UniProt
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Database links
- Entrez Gene: 554 Human
- Entrez Gene: 12000 Mouse
- Entrez Gene: 25108 Rat
- Omim: 300538 Human
- SwissProt: P30518 Human
- SwissProt: O88721 Mouse
- SwissProt: Q00788 Rat
- Unigene: 567240 Human
see all -
Alternative names
- ADHR antibody
- Antidiuretic hormone receptor antibody
- Arginine vasopressin receptor 2 antibody
see all
Images
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Western blot - Anti-AVPR V2 antibody (ab176488)Anti-AVPR V2 antibody (ab176488) at 2 µg/ml + Rat kidney extract at 20 µg
Predicted band size: 41 kDa
Protocols
Datasheets and documents
References
ab176488 has not yet been referenced specifically in any publications.
