Overview

  • Product name
    Anti-AVPR V2 antibody
    See all AVPR V2 primary antibodies
  • Description
    Rabbit polyclonal to AVPR V2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Rat AVPR V2 (N terminal). The exact sequence is proprietary.
    Database link: Q00788

  • Positive control
    • Rat kidney extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab176488 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Detects a band of approximately 50 kDa (predicted molecular weight: 41 kDa).
ELISA Use at an assay dependent concentration.

(cellular and membrane)

Target

  • Function
    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
  • Tissue specificity
    Kidney.
  • Involvement in disease
    Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]. This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis.
    Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI) [MIM:304800]; also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • ADHR antibody
    • Antidiuretic hormone receptor antibody
    • Arginine vasopressin receptor 2 antibody
    • AVP R2 antibody
    • AVPR 2 antibody
    • AVPR V2 antibody
    • AVPR2 antibody
    • DI1 antibody
    • DIR 3 antibody
    • DIR antibody
    • DIR3 antibody
    • MGC126533 antibody
    • MGC138386 antibody
    • NDI antibody
    • Nephrogenic diabetes insipidus antibody
    • Renal type arginine vasopressin receptor antibody
    • Renal-type arginine vasopressin receptor antibody
    • V2 receptor antibody
    • V2R antibody
    • V2R_HUMAN antibody
    • Vasopressin V2 antibody
    • Vasopressin V2 receptor antibody
    see all

Images

  • Western blot - Anti-AVPR V2 antibody (ab176488)
    Western blot - Anti-AVPR V2 antibody (ab176488)
    Anti-AVPR V2 antibody (ab176488) at 2 µg/ml + Rat kidney extract at 20 µg

    Predicted band size: 41 kDa

References

ab176488 has not yet been referenced specifically in any publications.

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