Key features and details
- Rabbit polyclonal to Axin 2
- Suitable for: IHC-P
- Reacts with: Rat
- Isotype: IgG
Product nameAnti-Axin 2 antibody
See all Axin 2 primary antibodies
DescriptionRabbit polyclonal to Axin 2
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Rat
Predicted to work with: Mouse, Human
- Rat brain and rat lymph node tissues.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 1% BSA, 50% Glycerol
Aqueous buffered solution
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab218023 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/500.|
FunctionInhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Tissue specificityExpressed in brain and lymphoblast.
Involvement in diseaseDefects in AXIN2 are involved in colorectal cancer (CRC) [MIM:114500]. They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]. Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
Sequence similaritiesContains 1 DIX domain.
Contains 1 RGS domain.
DomainThe tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.
modificationsProbably phosphorylated by GSK3B and dephosphorylated by PP2A.
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.
- Information by UniProt
- Axil antibody
- Axin like protein antibody
- Axin-2 antibody
Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat lymph node tissue labeling Axin 2 with ab218023 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat brain tissue labeling Axin 2 with ab218023 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
ab218023 has not yet been referenced specifically in any publications.