Anti-Axin 2 antibody - C-terminal (ab168826)

Rabbit polyclonal Axin 2 antibody. Validated in WB, IHC, Flow Cyt and tested in Human. Immunogen corresponding to synthetic peptide.


  • Product name
    Anti-Axin 2 antibody - C-terminal
    See all Axin 2 primary antibodies
  • Description
    Rabbit polyclonal to Axin 2 - C-terminal
  • Host species
  • Tested applications
    Suitable for: WB, IHC-P, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 823-843 of Human Axin 2 (UniProt: Q9Y2T1).

  • Positive control
    • Jurkat cell line lysate; Jurkat cells; Human brain tissue.



Our Abpromise guarantee covers the use of ab168826 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 93 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Flow Cyt 1/10 - 1/50.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.



  • Function
    Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
  • Tissue specificity
    Expressed in brain and lymphoblast.
  • Involvement in disease
    Defects in AXIN2 are involved in colorectal cancer (CRC) [MIM:114500]. They appear to be specifically associated with defective mismatch repair.
    Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]. Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
  • Sequence similarities
    Contains 1 DIX domain.
    Contains 1 RGS domain.
  • Domain
    The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.
  • Post-translational
    Probably phosphorylated by GSK3B and dephosphorylated by PP2A.
    ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.
    Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • Axil antibody
    • Axin like protein antibody
    • Axin-2 antibody
    • Axin-like protein antibody
    • Axin2 antibody
    • AXIN2_HUMAN antibody
    • Axis inhibition protein 2 antibody
    • Conductin antibody
    • DKFZp781B0869 antibody
    • MGC10366 antibody
    • MGC126582 antibody
    see all


  • Anti-Axin 2 antibody - C-terminal (ab168826) at 1/100 dilution + Jurkat cell line lysates at 35 µg

    Predicted band size: 93 kDa

  • Flow cytometric analysis of Jurkat cells (green) labeling Axin 2 with ab168826 at 1/10 dilution compred to a negative control cell (blue).
  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue labeling Axin 2 with ab168826 at 1/50 dilution.


ab168826 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab168826.
Please use the links above to contact us or submit feedback about this product.

For licensing inquiries, please contact

Sign up