Overview

  • Product name

    Azacyclonol (gamma-pipradol), ataractive agent
  • Description

    Ataractive agent
  • Biological description

    Ataractive agent. Terfenadine (ab120270) metabolite. Inhibits shock-induced elevation of catecholamine levels in the brain. Shows central depressant effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    115-46-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Diphenyl(piperidin-4-yl)methanol
  • Molecular weight

    267.37
  • Molecular formula

    C18H21NO
  • PubChem identifier

    15723
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 5 mM, in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Turncliff RZ  et al. Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes. J Pharmacol Exp Ther 318:881-9 (2006). Read more (PubMed: 16690724) »
  • Jurima-Romet M  et al. Induction of CYP3A and associated terfenadine N-dealkylation in rat hepatocytes cocultured with 3T3 cells. Cell Biol Toxicol 11:313-27 (1995). Read more (PubMed: 8788208) »
  • SATOH T & IWAMOTO T EFFECTS OF CHLORPROMAZINE, TETRABENAZINE AND AZACYCLONOL ON BRAIN SEROTONIN LEVEL OF SHOCKED RATS. Jpn J Pharmacol 14:161-5 (1964). Read more (PubMed: 14215544) »
  • Brown DA & Quilliam JP The effects of some centrally acting drugs on ganglionic transmission in the cat. Br J Pharmacol Chemother 23:241-56 (1964). Read more (PubMed: 19108183) »

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