Product nameAzaserine, serine derivative diazo compound
DescriptionSerine derivative diazo compound with antibiotic, antifungal and antineoplastic properties. Structural analog of glutamine.
- CN 15757
Serine derivative diazo compound with antibiotic, antifungal and antineoplastic properties. Structural analog of glutamine which competes with glutamine in binding to enzymes involved in purine biosynthesis. Inhibits the glutamine-dependent amidotransferases FGAM synthetase and glucosamine-6-phosphate isomerase. Inhibits the rate-limiting step of the hexosamine biosynthesis pathway (HBP) and irreversibly inhibits GGT1 (gamma-Glutamyltranspeptidase). Downregulates the expression of VCAM-1 and ICAM-1 in response to TNF-α. Protects against hyperglycemic endothelial damage through its antioxidant effect independently of inhibiting HBP pathway.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Soluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Rajapakse AG et al. The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects. Am J Physiol Heart Circ Physiol 296:H815-22 (2009). Read more (PubMed: 19136606) »
- Wada K et al. Crystal structures of Escherichia coli gamma-glutamyltranspeptidase in complex with azaserine and acivicin: novel mechanistic implication for inhibition by glutamine antagonists. J Mol Biol 380:361-72 (2008). Read more (PubMed: 18555071) »
- Lyons SD et al. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. J Biol Chem 265:11377-81 (1990). Read more (PubMed: 2358467) »