Product nameAzasetron hydrochloride, 5-HT3 receptor antagonist
DescriptionPotent, selective, competitive 5-HT3 receptor antagonist with antiemetic effects
- Azasetron HCl
- N-1-Azabicyclo[2.2.2]-oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide Hydrochloride
- Y-25130 HCl
- Y-25130 hydrochloride
Potent, selective, competitive 5-HT3 receptor antagonist (Ki = 0.33 nM) used in the management of nausea and vomiting induced by cancer chemotherapy.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 5 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Yamada Y et al. [Analysis of antiemetic effect of various dosage regimens of azasetron hydrochloride based on 5-HT3 receptor occupancy of serotonin]. Yakugaku Zasshi 127:353-7 (2007). Read more (PubMed: 17268155) »
- Katayama K et al. High affinity binding of azasetron hydrochloride to 5-hydroxytryptamine3 receptors in the small intestine of rats. Jpn J Pharmacol 73:357-60 (1997). Read more (PubMed: 9165374) »
- Haga K et al. The effects of orally administered Y-25130, a selective serotonin3-receptor antagonist, on chemotherapeutic agent-induced emesis. Jpn J Pharmacol 63:377-83 (1993). Read more (PubMed: 8107329) »
- Sato N et al. Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn J Pharmacol 59:443-8 (1992). Read more (PubMed: 1331590) »
- Fukuda T et al. The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur J Pharmacol 196:299-305 (1991). Read more (PubMed: 1654255) »