Azasetron hydrochloride, 5-HT3 receptor antagonist (ab145687)

Overview

  • Product name

    Azasetron hydrochloride, 5-HT3 receptor antagonist
  • Description

    Potent, selective, competitive 5-HT3 receptor antagonist with antiemetic effects
  • Alternative names

    • Azasetron HCl
    • N-1-Azabicyclo[2.2.2]-oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide Hydrochloride
    • Y-25130 HCl
    • Y-25130 hydrochloride
  • Biological description

    Potent, selective, competitive 5-HT3 receptor antagonist (Ki = 0.33 nM) used in the management of nausea and vomiting induced by cancer chemotherapy.

  • Purity

    > 99%
  • CAS Number

    123040-16-4
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    386.27
  • Molecular formula

    C17H20ClN3O3.HCl
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Yamada Y  et al. [Analysis of antiemetic effect of various dosage regimens of azasetron hydrochloride based on 5-HT3 receptor occupancy of serotonin]. Yakugaku Zasshi 127:353-7 (2007). Read more (PubMed: 17268155) »
  • Katayama K  et al. High affinity binding of azasetron hydrochloride to 5-hydroxytryptamine3 receptors in the small intestine of rats. Jpn J Pharmacol 73:357-60 (1997). Read more (PubMed: 9165374) »
  • Haga K  et al. The effects of orally administered Y-25130, a selective serotonin3-receptor antagonist, on chemotherapeutic agent-induced emesis. Jpn J Pharmacol 63:377-83 (1993). Read more (PubMed: 8107329) »
  • Sato N  et al. Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn J Pharmacol 59:443-8 (1992). Read more (PubMed: 1331590) »
  • Fukuda T  et al. The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur J Pharmacol 196:299-305 (1991). Read more (PubMed: 1654255) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145687.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up