Overview

  • Product name

    Azatadine maleate, H1 receptor antagonist
  • Description

    Potent, competitive H1 receptor antagonist. Various pharmacological effects.
  • Biological description

    Potent, competitive H1 receptor antagonist (IC50 = 6.5 nM) and 5-HT antagonist. Shows anticholinergic effects (IC50 = 11 nM). 5-HT antagonist. Inhibits mast cell degranulation. Shows antiallergic and sedative effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    3978-86-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    11-(1-Methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[3,4-b]pyridine maleate
  • Molecular weight

    522.55
  • Molecular formula

    C20H22N2.2C4H4O4
  • PubChem identifier

    16052003
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1CCC(=C2C3=CC=CC=C3CCC4=C2N=CC=C4)CC1.C(=CC(=O)O)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Baroody FM & Naclerio RM Antiallergic effects of H1-receptor antagonists. Allergy 55 Suppl 64:17-27 (2000). Read more (PubMed: 11291777) »
  • Singh N & Puri SK Causal prophylactic activity of antihistaminic agents against Plasmodium yoelii nigeriensis infection in Swiss mice. Acta Trop 69:255-60 (1998). Read more (PubMed: 9638277) »
  • van Wauwe JP & Goossens JG Arabinogalactan- and dextran-induced ear inflammation in mice: differential inhibition by H1-antihistamines, 5-HT-serotonin antagonists and lipoxygenase blockers. Agents Actions 28:78-82 (1989). Read more (PubMed: 2476925) »

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