Azathioprine, Antimetabolite and immunosuppressive agent (ab143064)

Overview

  • Product name

    Azathioprine, Antimetabolite and immunosuppressive agent
  • Description

    Antimetabolite and potent immunosuppressive agent. Purine analog.
  • Biological description

    Antimetabolite and potent immunosuppressive agent. Purine analog. 6-mercaptopurine (ab142389) prodrug. Inhibits DNA synthesis. Inhibits Rac1 and c-Jun-terminal-N-kinase activation. Shows antiproliferative effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    446-86-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Matsuo K  et al. Involvement of oxidative stress and immune- and inflammation-related factors in azathioprine-induced liver injury. Toxicol Lett 224:215-24 (2014). Read more (PubMed: 24184165) »
  • Marinkovic G  et al. Immunosuppressive drug azathioprine reduces aneurysm progression through inhibition of Rac1 and c-Jun-terminal-N-kinase in endothelial cells. Arterioscler Thromb Vasc Biol 33:2380-8 (2013). Read more (PubMed: 23950142) »
  • Cegiela U  et al. Alendronate prevents development of the skeletal changes induced by azathioprine in rats. Acta Pol Pharm 70:309-15 (0). Read more (PubMed: 23614287) »

Customer reviews and Q&As

Answer



I can confirm the following:


1. The Azathioprine (Azasan, Imuran) can be dissolved in DMSO up to a concentration of 54 mg/mL.


2. The molecule is quite small so it should be fine in sterile filtering. However this is not something we test so regrettably we cannot guarantee it.


3. The stocks can be stored for up to 6 months at -80°C in DMSO.

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