Overview

  • Product name

    AZD1152-HQPA, Aurora B kinase inhibitor
  • Description

    Potent, selective Aurora B kinase inhibitor
  • Biological description

    Potent, selective Aurora B kinase inhibitor (IC50 = 0.37 nM). Induces apoptosis in vitro. Antitumor agent. Cell-permeable. Active in vitro and in vivo.
  • Purity

    > 99%
  • CAS Number

    722544-51-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide
  • Molecular weight

    507.56
  • Molecular formula

    C26H30FN7O3
  • PubChem identifier

    16007391
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tao Y  et al. Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152. Oncogene 27:3244-55 (2008). Read more (PubMed: 18084327) »
  • Walsby E  et al. Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts. Haematologica 93:662-9 (2008). Read more (PubMed: 18367484) »
  • Yang J  et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood 110:2034-40 (2007). Read more (PubMed: 17495131) »

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