AZD4547, FGFR inhibitor (ab216311)
Key features and details
- Novel, selective FGFR inhibitor
- CAS Number: 1035270-39-3
- Purity: > 98%
DMSO (>80 mg/ml)
- Form / State: Solid
Overview
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Product name
AZD4547, FGFR inhibitor -
Description
Novel, selective FGFR inhibitor -
Alternative names
- AZD-4547
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Biological description
Novel, selective inhibitor of the FGFR1, 2, and 3 tyrosine kinases. Binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, thus resulting in the inhibition of tumor cell proliferation and tumor cell death.
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Purity
> 98% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 9403 AZD-4547. 9403-25 is the same size as the 25 mg size of ab216311.
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CAS Number
1035270-39-3 -
Chemical structure
Properties
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Chemical name
N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide
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Molecular weight
463.57 -
Molecular formula
C26H33N5O3 -
PubChem identifier
51039095 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions. -
Solubility overview
DMSO (>80 mg/ml)
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Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(Nc2cc(CCc1cc(OC)cc(OC)c1)nn2)c3ccc(cc3)N4C[C@H](C)N[C@H](C)C4 -
Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab216311 has been referenced in 2 publications.
- O'Brien A et al. FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2-/- Mouse Model of Primary Sclerosing Cholangitis. Hepatol Commun 6:1574-1588 (2022). PubMed: 35271760
- Akazawa Y et al. Recruitment of mesenchymal stem cells by stromal cell-derived factor 1a in pulp cells from deciduous teeth. Int J Mol Med 36:442-8 (2015). PubMed: 26082290