Overview

  • Product name

    AZD4547, FGFR inhibitor
  • Description

    Novel, selective FGFR inhibitor
  • Alternative names

    • AZD-4547
  • Biological description

    Novel, selective inhibitor of the FGFR1, 2, and 3 tyrosine kinases. Binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, thus resulting in the inhibition of tumor cell proliferation and tumor cell death. 

  • Purity

    > 98%
  • CAS Number

    1035270-39-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide

  • Molecular weight

    463.57
  • Molecular formula

    C26H33N5O3
  • PubChem identifier

    51039095
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    DMSO (>80 mg/ml)

  • SMILES

    O=C(Nc2cc(CCc1cc(OC)cc(OC)c1)nn2)c3ccc(cc3)N4C[C@H](C)N[C@H](C)C4

References

This product has been referenced in:

  • Kwak Y  et al. Antitumor Effects and Mechanisms of AZD4547 on FGFR2-Deregulated Endometrial Cancer Cells. Mol Cancer Ther 14:2292-302 (2015). Read more (PubMed: 26294741) »
  • Doughton G  et al. Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling. PLoS One 9:e95434 (2014). Read more (PubMed: 24752320) »
  • Gavine PR  et al. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res 72:2045-56 (2012). Read more (PubMed: 22369928) »

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