Overview

  • Product name

    AZD7762, Chk inhibitor
  • Description

    Potent, selective Chk inhibitor
  • Biological description

    Potent, selective Chk inhibitor (IC50 values are 5 and <10 nM for Chk1 and Chk2 respectively). Reversibly binds to the ATP binding site (Ki = 3.6 nM, Chk1). Induces cell cycle arrest. Potentiates the antitumor activity of gemcitabine (ab145657) in vivo.
  • Purity

    > 95%
  • CAS Number

    860352-01-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Lu M  et al. Alternation of adriamycin penetration kinetics in MCF-7 cells from 2D to 3D culture based on P-gp expression through the Chk2/p53/NF-?B pathway. Biochem Pharmacol 93:210-20 (2015). Read more (PubMed: 25478729) »
  • Morgan MA  et al. Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res 70:4972-81 (2010). Read more (PubMed: 20501833) »
  • Zabludoff SD  et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol Cancer Ther 7:2955-66 (2008). Read more (PubMed: 18790776) »

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