Azelaic acid (Nonanedioic acid), 5alpha reductase inhibitor (ab143467)

Overview

  • Product name

    Azelaic acid (Nonanedioic acid), 5alpha reductase inhibitor
  • Description

    5α reductase inhibitor. PPARγ activator.
  • Biological description

    5α reductase inhibitor. PPARγ activator. Competitively inhibits tyrosinase and thioredoxin reductase (Ki values are 3 mM and 13 μM respectively). Cytotoxin to melanocytes. Reduces skin hyperpigmentation. Induces salicylic acid accumulation in plants. Shows anti-inflammatory and antibiotic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    123-99-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Nonanedioic acid
  • Molecular weight

    188.22
  • Molecular formula

    C9H16O4
  • PubChem identifier

    2266
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM, in DMSO to 100 mM and in ethanol (with heating)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C(CCCC(=O)O)CCCC(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Briganti S  et al. Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPAR?. Exp Dermatol 22:41-7 (2013). Read more (PubMed: 23278893) »
  • Schallreuter KU & Wood JW A possible mechanism of action for azelaic acid in the human epidermis. Arch Dermatol Res 282:168-71 (1990). Read more (PubMed: 2114832) »
  • Stamatiadis D  et al. Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol 119:627-32 (1988). Read more (PubMed: 3207614) »

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